Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrier

• Yamei Zhao,
• Wei Tian,
• Guang Yang and
• Xiaodong Fan

Beilstein J. Org. Chem. 2014, 10, 2696–2703, doi:10.3762/bjoc.10.284

• Technology, School of Science, Northwestern Polytechnical University, Xi’an, 710072, P. R. China 10.3762/bjoc.10.284 Abstract In this paper, a novel, multifunctional polymer nanocarrier was designed to provide adequate volume for high drug loading, to afford a multiregion encapsulation ability, and to

• ; hyperbranched polymer; multifunctionality; polymer nanocarrier; Introduction In recent years, many nanostructured materials (such as polymeric micelles) used as pharmaceutical nanocarriers have been applied in different fields of biomedicine for controlled release, diagnostics, imaging, treatment and

•  1B, P2), the drug loading capacity of the polymer nanocarrier may be enhanced due to the existence of inner cavities from the hyperbranched topological structure. Additionally, the outer shell functionality of the polymer nanocarrier can be expanded to encapsulate more drugs due to the introduction